The study was carried out to develop an emulgel formulation of antifungal drug Bifonazole. The drug had the poor solubility and poor permeability (BCS Class-IV). So to enhance the solubility and permeability of the drug, it was first incorporated in emulsion and then emulsion was mixed with the gel. The polymer used in the gel was Carbopol 934 and HPMC K4M. The 23 factorial design was used for the study. The evaluation parameters were Physical Properties, Viscosity, spreadability and %drug release, antifungal activity and stability study was done. Commercially available Bifonazole cream was used for the comparison. It was found that the emulsifying agent had prominent effect of the drug release in emulgel followed by the oil phase as well as the gelling type. Stability studies shows that the physical appearance, viscosity, drug content, % drug release were unchanged upon three months of the storage. At the end of the investigation it was observed that the Carbopol 934 was the choice of polymer as it has shown higher drug release and good antifungal activity.
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